Closantel Sodium Dihydrate

Product Name: Closantel Sodium

Properties (Reference):

Mechanism of action of Closantel Sodium:
The molecular mode of action of salicylanilides, including closantel, is not completely elucidated. They all are uncouplers of the oxidative phosphorylation in the cell mitochondria, which disturbs the production of ATP, the cellular “fuel”. This seems to occur through suppression of the activity of succinate dehydrogenase and fumarate reductase, two enzymes involved in this process. This impairs the parasites motility and probably other processes as well. It seems that closantel also disturbs the liquid and ion transport mechanisms in the parasites membranes.
Recently it has been discovered that closantel also inhibits chitinase in Onchocerca volvulus, a filarial nematode causing river blindness in humans. Chitinase is an enzyme involved in larval molting. Its inhibition interrupts their development to adult worms.

Closantel Side Effects, Adverse Drug Reactions (ADRs) and Warnings:

• In goats, subcutaneous injection of closantel can cause brief but strong pain at the injection site.
• At therapeutic doses closantel usually does con cause ADRs, excepting those previously described but in a mild and transient form.
• The combination of closantel and ivermectin does not affect the pharmacological behavior of closantel.